HbA1c Direct
Immunoturbidimetric method
| REF | Volume |
|---|---|
| N/A | N/A |
Product description:
Glycosylated haemoglobin (HbA1c) is a minor fraction of adult haemoglobin, which is formed
slowly and non-enzymatically from haemoglobin and glucose. The accumulation of glucose in red
blood cells under hyperglycaemic conditions favour the formation of glycated product- the HbA1c.
The formation of HbA1c is a slow reaction that is dependent on the prevailing concentration of
blood glucose; it continues irreversibly throughout the red blood cell's life span of
approximately 120 days. The higher the blood glucose concentration and the longer the red blood
cell's exposure to it makes higher the fraction of HbA1c, which is expressed as a percentage of
total haemoglobin. Because a blood sample at any given time contains a mixture of red blood
cells of varying ages, exposed for varying times to varying blood glucose concentrations, a
HbA1c measurement reflects the average blood glucose concentration from the preceding 2-3
months.
Measurements of HbA1c have proved to be a useful index of glycaemic control over last two
decades. It is currently recommended that HbA1c measurements be obtained 3-4 times in a year to
obtain a profile of long-term glycemic control. The lower the HbA1c level, the more likely it is
that microvascular complications such as retinopathy and nephropathy will be less severe,
delayed in appearance, or even avoided altogether.
